Blog Image

The Essential Guide to Bone Marrow Transplant in India

15 Jun, 2024

Blog author iconDr. Divya Nagpal
Share

Dealing with blood cancers like leukaemia and lymphoma can be overwhelming. They not only affect your health but also bring immense stress to you and your loved ones. The constant hospital visits, ongoing treatments, and uncertain outcomes can feel like an uphill battle. And the fear of complications and the search for a compatible donor only add to the challenges. But there's hope in bone marrow transplant (BMT). This procedure isn't just about treatment—it's about potentially finding a cure. By replacing damaged marrow with healthy stem cells, BMT restores your body's ability to produce normal blood cells and strengthens your immune system. Thanks to advancements in medical technology and improved donor availability, BMTs are becoming more accessible and effective than ever before. So, while the journey may seem daunting, know that BMT offers a pathway to long-term health and recovery. It's about more than just treatment; it's about regaining your life and looking forward to a brighter future.


Transform Your Beauty, Boost Your Confidence

Find the right cosmetic procedure for your needs.

Healthtrip icon

We specialize in a wide range of cosmetic procedures

Procedure

Bone Marrow Transplant Procedure

A bone marrow transplant (BMT) is a complex medical procedure aimed at replacing damaged or diseased bone marrow with healthy stem cells. This process involves several stages, each crucial to the success of the transplant. Here’s a detailed breakdown of the procedure:


Calculate Treatment Cost, Check Symptoms, Explore Doctors and Hospitals

1. Pre-transplant Evaluation

Before the transplant, the patient undergoes a thorough evaluation to ensure they are fit for the procedure. This phase includes:

  • Medical History and Physical Examination: A detailed review of the patient's medical history and a physical examination to assess overall health.
  • Blood Tests: Comprehensive blood tests to check the patient’s blood cell counts, liver and kidney function, and to screen for infections.
  • Imaging Tests: Tests such as X-rays, CT scans, and MRIs to assess the condition of the patient’s organs and detect any abnormalities.
  • Bone Marrow Biopsy: A procedure to examine the bone marrow's condition and confirm the diagnosis.
  • Psychological Evaluation: Assessment of the patient's mental health to ensure they can cope with the stresses of the transplant process.
  • Organ Function Tests: Evaluations of the heart, lungs, and other vital organs to ensure they can withstand the transplant and associated treatments.

2. Donor Selection and Harvesting


Depending on the type of transplant, the source of healthy stem cells can vary:

  • Autologous Transplant: The patient's own stem cells are collected and stored for later use.
  • Allogeneic Transplant: Stem cells are collected from a compatible donor, often a sibling or unrelated matched donor.
  • Umbilical Cord Blood Transplant: Stem cells are collected from the umbilical cord blood of a newborn.

Stem cell harvesting involves:

Most popular procedures in

Total Hip Replacemen

Upto 80% off

90% Rated

Satisfactory

Total Hip Replacement (Unilateral)

Total Hip Replacemen

Upto 80% off

90% Rated

Satisfactory

Total Hip Replacement (B/L)

Breast Cancer Surger

Upto 80% off

90% Rated

Satisfactory

Breast Cancer Surgery

Total Knee Replaceme

Upto 80% off

90% Rated

Satisfactory

Total Knee Replacement-B/L

Total Knee Replaceme

Upto 80% off

90% Rated

Satisfactory

Total Knee Replacement-U/L
  • Peripheral Blood Stem Cell Collection: The donor is given medication to increase stem cell production, followed by apheresis, where blood is drawn, stem cells are separated, and the remaining blood is returned to the donor.
  • Bone Marrow Harvesting: Under general anesthesia, a needle is inserted into the donor’s pelvic bone to extract bone marrow.

3. Conditioning


Conditioning involves preparing the patient’s body to receive the new stem cells. This phase includes:

  • High-dose Chemotherapy: Administered to destroy the patient’s diseased bone marrow and to suppress the immune system to prevent rejection of the new stem cells.
  • Radiation Therapy: Total body irradiation (TBI) may be used alongside chemotherapy to eradicate any remaining diseased cells and create space for the new stem cells.

4. Transplant Day (Day 0)


On the day of the transplant, healthy stem cells are infused into the patient’s bloodstream through a central venous catheter. This process is similar to a blood transfusion and typically takes several hours. The stem cells then travel to the bone marrow, where they begin to engraft and produce new blood cells.

5. Engraftment and Recovery


Engraftment is the process where the new stem cells settle in the bone marrow and start to produce new blood cells. This phase can last several weeks and involves:

  • Close Monitoring: Frequent blood tests and physical exams to monitor the patient’s progress and detect any complications early.
  • Supportive Care: Administration of medications to prevent infections, manage side effects, and support overall health.
  • Transfusions: Blood and platelet transfusions may be necessary to support the patient until the new marrow begins to function properly.
  • Isolation: To reduce the risk of infections, patients are often kept in a sterile environment with limited contact.

6. Post-transplant Care and Long-term Follow-up


Long-term follow-up care is crucial for the success of the transplant and includes:

  • Regular Check-ups: Frequent visits to the transplant centre for physical exams, blood tests, and monitoring of organ function.
  • Immunosuppressive Therapy: Medications to prevent graft-versus-host disease (GVHD) in allogeneic transplants.
  • Infection Prevention: Continued use of antibiotics, antivirals, and antifungals to prevent infections.
  • Rehabilitation: Physical therapy and occupational therapy to help regain strength and function.
  • Psychosocial Support: Counseling and support groups to help the patient and their family cope with the emotional and psychological aspects of recovery.
  • Lifestyle Adjustments: Adopting a healthy lifestyle, including a balanced diet, regular exercise, and avoiding exposure to infections.

The entire process, from pre-transplant evaluation to long-term follow-up, requires close coordination between the patient, their family, and a multidisciplinary team of healthcare professionals to ensure the best possible outcome.


Bone Marrow Transplant Doctors in India

1. Dr. Rahul Bhargava

Dr Rahul Bhargava, [object Object]

Position: Director - Blood Disorders and Bone Marrow Transplant

Consults at:

  • Fortis Memorial Research Institute, Gurgaon
  • Fortis Hospital, Noida

Ratings: 5.0

Surgeries: 800

Experience: 15 years

Get A Consultation

About

Dr Rahul Bhargava is renowned for being the first Indian doctor to popularize stem cell transplants in multiple sclerosis. With over 400 successful transplants, he is considered one of the best stem cell transplant experts in Delhi and Gurgaon. His vision of creating the first integrated centre of excellence in haematology, paediatric haematology, and stem cell transplant has been realized at Fortis Memorial Research Institute. Dr. Bhargava is also actively involved in community awareness around blood disorders.

Areas of Interest

  • Benign Haematology and Haematology
  • Paediatric Hematoncology
  • Matched Sibling, Unrelated, and Haploidentical Transplants
  • Hematopathology and Molecular Haematology

Previous Experience:

  • MBBS and MD in Medicine from Bhopal, Madhya Pradesh
  • Senior Resident in the Department of Haematology and Stem Cell Transplant at CMC Vellore
  • DM graduate from AIIMS, New Delhi
  • Established the first stem cell transplant centre at Medanta the Medicity, Gurgaon, completing 100 transplants in 2 years
  • Head of Haematology at Artemis, where he performed the first haploidentical transplant in Gurgaon

Specialization: Hematologist and Pediatrician

Experience: 31 years

Consults at:

  • Apollo Cancer Centres, Chennai

Education:

  • MBBS from Madras University, Chennai, India (1991)
  • Diploma in Child Health (DCH) from The Tamil Nadu Dr. M.G.R. Medical University (TNMGRMU) (1993)
  • FRC.PATH. (U.K.) from The Royal College of Pathologists (2008)

Professional Memberships:

  • Indian Medical Association (IMA)

Services Offered: Blood transfusion, stem cell transplantation, wellness screening, haemophilia care, lymphatic drainage, bone marrow transplant, eosinophilia treatment, thalassemia care, and chelation therapy.

Dr. Revathi Raj is a highly experienced haematologist and paediatrician, with over three decades of practice. She provides specialized care in bone marrow transplants and various other treatments related to haematology and paediatrics at Apollo Cancer Centres in Chennai.


Bone Marrow Transplant Hospitals in India

1. Apollo Hospitals, Chennai:

Apollo Hospital

Apollo Hospitals on Greams Road in Chennai was established in 1983 by Dr. Prathap C Reddy. It was India's first corporate hospital and is acclaimed for pioneering the private healthcare revolution in the country. Over the years, Apollo Hospitals has risen to a position of leadership, emerging as Asia's foremost integrated healthcare services provider.

Location

  • Address: 21 Greams Lane, Off Greams Road, Thousand Lights, Chennai, Tamil Nadu 600006, India
  • City: Chennai
  • Country: India

Hospital Features

  • Established Year: 1983
  • Treatment Availability: International
  • Hospital Category: Medical
  • Status: Active
  • Visibility on Website: Yes

About Apollo Hospitals

Apollo Hospitals has a robust presence across the healthcare ecosystem, including hospitals, pharmacies, primary care, and diagnostic clinics. The Group also has telemedicine units across 10 countries, health insurance services, global projects consultancy, medical colleges, Med-varsity for e-learning, colleges of nursing, and hospital management.

Team and Specialties

  • Cardiology and Cardiothoracic Surgery: Apollo Hospitals hosts one of the largest cardiovascular groups globally, with around 14 world-class institutes, over 400 cardiologists & cardiac surgeons, and 200 heart stations.
  • Robotic Spinal Surgery: Among the few centres in Asia to perform this advanced procedure, Apollo is at the forefront of spinal disorder management.
  • Cancer Care: A 300-bedded, NABH-accredited hospital providing advanced technology in diagnosis and radiation, supported by an oncology team of renowned specialists and well-trained medical and paramedical professionals.
  • Gastroenterology: Offers the latest endoscopic procedures for gastrointestinal bleeding, cancers, foreign body removal, etc.
  • Transplant Institutes: The Apollo Transplant Institutes (ATI) is one of the largest, most comprehensive, and busiest solid transplant programs globally.
  • Liver Surgery: Equipped with a 320-slice CT scanner, a state-of-the-art Liver Intensive Care Unit & Operation Theatre, and various surgical tools to enable safe & bloodless liver surgery.
  • Neurosurgery: Recognized as a leader in acute neurosurgery, Apollo Hospitals, Chennai, is among the top hospitals specializing in neuro care worldwide.

Infrastructure

With the experience of over one million health checks, Apollo Hospitals has emerged as a key player in the corporate healthcare sector. Over 500 leading corporates, across all industry segments, have tied up with Apollo Hospitals, providing their employees ready access to sophisticated medical facilities at over 64 locations in India. The corporate services initiative of Apollo Hospitals, Chennai, aims to provide world-standard healthcare within the reach of every individual.



Specialties:

  • Joint Replacement Surgery: Renowned for joint replacement surgeries using advanced techniques and computer navigation.
  • Bariatric Surgery: Offers a comprehensive weight loss surgery program, including laparoscopic and robotic bariatric procedures.
  • Organ Transplant Program: Provides liver, kidney, and heart transplants with a high success rate.
  • Oncology: Offers medical, surgical, and radiation oncology services, including advanced cancer therapies.
  • Cardiology: Provides advanced cardiac care, including minimally invasive procedures, interventional cardiology, and cardiac electrophysiology.

Technology:

  • Advanced diagnostic tools like PET CT scan, 3 Tesla MRI, and high-resolution CT scan.
  • Robotic surgical systems like Da Vinci Xi for minimally invasive surgeries.
  • Cutting-edge cath labs for complex cardiac procedures.
  • Advanced radiation therapy equipment for precise cancer treatment.

Patient Services:

  • International patient services team to assist with travel arrangements and medical visa applications.
  • Dedicated patient care coordinators to guide patients throughout their treatment journey.
  • Comfortable and well-equipped patient rooms with a range of accommodation options.
  • Support services like physiotherapy, nutritional counselling, and psychological counselling.

3. Max Smart Super Speciality Hospital, Saket

Max Smart Super Speciality Hospital, Saket


Max Super Speciality Hospital, Saket is one of the leading multispecialty hospitals in India, located in the heart of South Delhi. It is part of the Max Healthcare brand, which has a network of hospitals and healthcare facilities all over India.

Here's a summary of the Max Super Speciality Hospital, Saket:

  • Established: 2006
  • Number of beds: 530+
  • Accreditations: JCI, NABH, NABL
  • Specialities: Over 38 specialities including Cardiology, Oncology, Neurology, Neurosurgery, Nephrology, Urology, Transplant services (Heart, Lung, Liver, Kidney, Bone Marrow), Metabolic and Bariatric Surgery, Obstetrics and Gynaecology, Aesthetics & Reconstructive Surgery, and many other ancillary medical services.

Here are some of the reasons why Max Super Speciality Hospital, Saket is considered one of the best hospitals in India:

  • Advanced diagnostic and therapeutic technologies: The hospital is equipped with the latest technologies for diagnosis and treatment, including several first-in-India and Asia machines.
  • Team of experienced doctors: The hospital has a team of highly qualified and experienced doctors from various specialities.
  • Comprehensive care: The hospital provides comprehensive care for a wide range of medical conditions, from simple to complex.
  • Focus on patient care: The hospital is committed to providing quality care to its patients and has a patient-centric approach.


Bone Marrow Transplant Cost in India


Generally, the cost of a bone marrow transplant in India ranges from ₹15,00,000 to ₹40,00,000 (approximately USD 18,000 to $48,000).


Factors Affecting Cost:

1. Type of Transplant: There are two main types:

  • Autologous: Using your bone marrow.
  • Allogeneic: Using bone marrow from a donor. Allogeneic transplants are typically more expensive.

2. Hospital Facilities: The reputation and amenities offered by the hospital can impact the cost.

3. Donor Search & Matching: If an allogeneic transplant is needed, the cost of searching for and matching a donor can add to the overall bill.

4. Post-operative Care: The extent of aftercare needed, including medications and potential complications, can influence the total cost.


Recommendations:


To get a more accurate estimate for your specific situation, it's advisable to:

  • Contact Hospitals Directly: Reach out to hospitals you're considering to get a quote based on your specific condition and transplant type.

  • Explore Online Resources: Certain medical tourism websites or hospital websites might offer cost estimates for different BMT procedures.

  • Bone Marrow Transplant Success Rate in India

    Success rates for bone marrow transplants in India depend on several factors:

    • General Range: Success rates in India generally range between 60% and 80%.

  • Variations by Factors:

    • Type of Transplant: Autologous transplants often have slightly higher success rates than allogeneic transplants.
    • Patient's Age & Health: A younger patient with a good overall health condition generally has a better prognosis.
    • Underlying Condition: The success rate can vary depending on the disease being treated with the transplant.
    • Hospital & Doctor Experience: A well-established hospital with experienced doctors specializing in BMT can significantly influence success rates.

    How can HealthTrip assist with your treatment?

    If you're seeking a Bone Marrow Transplant in India, let HealthTrip be your compass. We support you throughout your medical journey with the following:

    • Access to top doctors in 38+ countries and the largest health travel platform.
    • Partnerships with 1500+ hospitals, including Fortis, Medanta, and more.
    • Treatments in neuro, cardiac care, transplants, aesthetics, and wellness.
    • Post-treatment care and assistance.
    • Teleconsultations with leading doctors at $1/minute.
    • Over 61K patients served.
    • Access Top treatments and packages, such as Angiograms and many more.
    • Gain insights from genuine patient experiences and testimonials.
    • Stay updated with our medical blog.
    • 24/7 unwavering support, from hospital formalities to travel arrangements or emergencies.

    Hear from our satisfied patients.

    Risks Associated with Bone Marrow Transplants

  • a. Graft-versus-Host Disease (GVHD): Donor immune cells attack recipient tissues, potentially affecting the skin, liver, and digestive tract. Managed with immunosuppressive medications.

  • b. Graft Failure: Transplanted cells may fail to engraft, delaying recovery or requiring re-transplantation.

  • c,. Infection: A weakened immune system increases susceptibility to severe infections, necessitating prompt treatment with antibiotics or antivirals.

  • d. Organ Damage: Chemotherapy or radiation can damage organs like the lungs, liver, or kidneys, impacting overall recovery and health.

  • e. Bleeding and Anemia: Low blood cell counts post-transplant can lead to bleeding and anaemia, often requiring blood transfusions and supportive care.

  • f. Long-term Effects: Possible complications include infertility, cataracts, or secondary cancers, requiring ongoing monitoring and early intervention.

  • g. Psychological and Emotional Impact: Coping with the physical challenges and uncertainties of recovery can have a significant psychological impact, necessitating supportive care and counselling.


  • Post-Transplant Care and Recovery


    After your bone marrow transplant, the focus shifts to careful monitoring and support to help you recover smoothly:


    a. Regular Monitoring You'll have frequent check-ups to monitor your vital signs, blood counts, and immune system. This helps catch any potential issues early on and ensures your recovery progresses well.


    b. Infection Prevention Protecting your weakened immune system is crucial. You'll continue with preventive measures such as antibiotics and antivirals to reduce the risk of infections.


    c. Medication Management You'll still need to take immunosuppressive medications to prevent your body from rejecting the transplant and to manage conditions like GVHD. Your doctors will adjust these medications as needed.


    These steps, along with nutrition support, physical recovery exercises, emotional support, and ongoing education, are all part of ensuring your best possible recovery and long-term health post-transplant.


    Bone marrow transplants (BMT) are a lifeline for patients with serious blood disorders like leukaemia and lymphoma. In India, hospitals like Apollo, BLK, and Max provide advanced care and facilities for BMT, ensuring better outcomes through thorough evaluations and expert post-transplant care.

    Healthtrip icon

    Wellness Treatments

    Give yourself the time to relax

    certified

    Lowest Prices Guaranteed!

    Treatments for Weight loss, Detox, Destress, Traditional Treatments, 3 day healthtrip and more

    95% Rated Great Experience and Relaxing

    Get in touch
    Please fill in your details, Our experts will get in touch with you

    FAQs

    Recovery can take several months to a year, involving gradual return to normal activities, ongoing medical monitoring, and lifestyle adjustments to support health and prevent infections.