By Healthtrip Team Blog Published on - 12 October - 2023

A Comprehensive Guide to Small Intestine Cancer

Small intestine cancer

Small intestine cancer is a rare but impactful condition that involves the abnormal growth of cells within the small intestine, a crucial component of the digestive system. Situated between the stomach and the large intestine, the small intestine plays a vital role in absorbing nutrients from the food we consume. Small intestine cancer encompasses various types, each with distinct characteristics and implications. Understanding this condition is essential for early detection, effective management, and improving the overall outlook for individuals facing this challenge.

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A. Adenocarcinoma:

This type of small intestine cancer originates in the cells that line the inner surface of the small intestine. Adenocarcinomas are the most common form, accounting for a majority of cases.

B. Sarcoma:

Sarcomas develop in the connective tissues, such as muscles or blood vessels, within the small intestine. They are less common than adenocarcinomas but present unique challenges in terms of diagnosis and treatment.

C. Carcinoid Tumors:

Carcinoid tumors are slow-growing neuroendocrine tumors that can occur in the small intestine. They are known for producing hormones and may lead to symptoms associated with hormone imbalances.

D. Gastrointestinal Stromal Tumors (GIST):

GISTs are a rare type of cancer that begins in the stromal cells of the gastrointestinal tract, including the small intestine. These tumors can vary in behavior, and treatment approaches often involve targeted therapies.

Symptoms and Signs

  • Abdominal Pain: Persistent or crampy abdominal pain, particularly in the midsection, may be a symptom of small intestine cancer.
  • Unexplained Weight Loss: Sudden and unexplained weight loss, not attributable to changes in diet or physical activity, can be a red flag for various cancers, including small intestine cancer.
  • Changes in Bowel Habits: Alterations in bowel habits, such as persistent diarrhea or constipation, may signal an issue within the small intestine.
  • Blood in the Stool: The presence of blood in the stool, which can manifest as dark, tarry stools or visible red blood, is a concerning symptom that requires prompt medical attention.


  • Genetic Factors: Certain genetic predispositions may increase the likelihood of developing small intestine cancer, especially in individuals with a family history of gastrointestinal cancers.
  • Environmental Factors: Exposure to environmental factors, such as radiation or certain chemicals, may contribute to the development of small intestine cancer.
  • Inflammatory Conditions: Chronic inflammatory conditions affecting the small intestine, like Crohn's disease, could elevate the risk of cancer over time. Inflammation may lead to cellular changes that increase the likelihood of cancerous growth.


A. Imaging Tests (CT Scans, MRIs):

Advanced imaging techniques, such as computed tomography (CT) scans and magnetic resonance imaging (MRI), play a crucial role in visualizing the structure of the small intestine. These tests help identify abnormalities, such as tumors, and provide valuable information for further diagnostic steps.

B. Endoscopic Procedures (Endoscopy, Colonoscopy):

Endoscopic procedures involve the use of a flexible tube with a camera to examine the interior of the small intestine. Endoscopy focuses on the upper part of the small intestine, while colonoscopy examines the lower part. These procedures allow direct visualization of the intestinal lining, and biopsies can be taken during the process for further examination.

C. Biopsy for Confirmation:

To confirm the presence of cancer, a biopsy is typically performed. During this procedure, a small tissue sample is taken from the suspicious area in the small intestine. The sample is then examined under a microscope by a pathologist to determine the presence of cancer cells and the specific type of cancer. Biopsy results are critical for guiding treatment decisions and understanding the nature of the cancer.


A. Surgery:

Surgical intervention is a primary treatment for small intestine cancer. The extent of surgery depends on the size and location of the tumor. Surgeons may perform a resection to remove the cancerous portion of the small intestine, and in some cases, nearby lymph nodes may also be removed to prevent the spread of cancer.

B. Chemotherapy:

Chemotherapy involves the use of drugs to kill or slow the growth of cancer cells. It is often employed after surgery to eliminate any remaining cancer cells or as a primary treatment when surgery is not feasible. The drugs can be administered orally or intravenously and travel throughout the body to target cancer cells.

C. Radiation Therapy:

Radiation therapy utilizes high-energy beams to target and destroy cancer cells. While less common in small intestine cancer compared to other gastrointestinal cancers, it may be recommended in certain cases, especially when the tumor is inoperable or to shrink the tumor before surgery.

D. Targeted Therapy:

Targeted therapy focuses on specific molecules involved in the growth and spread of cancer cells. This type of treatment is tailored to the characteristics of the cancer cells and aims to interfere with specific pathways, minimizing damage to healthy cells. Targeted therapy may be used alone or in combination with other treatments.

Risk Factors

1. Family History of Gastrointestinal Cancers: Individuals with a family history of gastrointestinal cancers, including colon, rectal, and stomach cancers, have an elevated risk of developing small intestine cancer. This increased risk is attributed to shared genetic factors and possibly similar lifestyle or environmental exposures within families.

2. Previous Radiation Exposure: Those who have undergone radiation therapy, particularly involving the abdomen, for other cancers or medical conditions, face a heightened risk. The exposure to radiation can induce changes in the cells of the small intestine, increasing the likelihood of malignant transformations.

3.Certain Genetic Conditions: Specific inherited genetic disorders, such as Hereditary Nonpolyposis Colorectal Cancer (HNPCC) or Lynch syndrome, are linked to a predisposition for small intestine cancer. These conditions involve mutations in DNA mismatch repair genes, which normally help prevent cancer by correcting DNA replication errors.

4. Dietary Habits: Some studies suggest that a diet high in red and processed meats might increase the risk of small intestine cancer, while diets rich in fruits and vegetables may have a protective effect.


1. Bowel Obstruction: A common complication where the tumor physically blocks the small intestine. This can lead to severe abdominal pain, vomiting, constipation, and swelling of the abdomen. Emergency treatment might be necessary in severe cases.

2. Malabsorption Issues: Cancer of the small intestine can interfere with the absorption of nutrients from food. This leads to malnutrition, weight loss, and deficiencies in vitamins and essential nutrients, further complicating the patient's health status.

3. Spread to Other Organs (Metastasis): In advanced stages, small intestine cancer can metastasize, spreading to other organs like the liver, lungs, or peritoneal cavity. This significantly complicates treatment and typically worsens the prognosis.

4. Secondary Conditions: Apart from bowel obstruction and malabsorption, small intestine cancer can also lead to conditions like anemia (due to chronic blood loss in the gastrointestinal tract) and ascites (fluid accumulation in the abdomen).


1. Lifestyle Changes: Adopting a healthy lifestyle can reduce the risk of small intestine cancer. This includes maintaining a balanced diet rich in fruits, vegetables, and whole grains, regular physical activity, and avoiding tobacco products and excessive alcohol consumption.

2. Screening for High-Risk Individuals: People with a known family history of gastrointestinal cancers or those with genetic predispositions such as HNPCC should undergo regular screenings. These may include endoscopic procedures like a colonoscopy or specialized imaging tests to detect early signs of cancer, facilitating early intervention and improved outcomes.

3. Regular Medical Check-ups: For individuals not at high risk, regular health check-ups that include discussions about gastrointestinal health can be beneficial. Reporting any unusual symptoms like unexplained abdominal pain or changes in bowel habits to a healthcare provider promptly can aid in early detection.

In brief, understanding small intestine cancer's nuances is crucial. Timely detection and intervention play a pivotal role in enhancing treatment effectiveness and overall outcomes, underscoring the significance of proactive medical attention.


Small intestine cancer involves abnormal cell growth in the small intestine.
Common types include adenocarcinoma, sarcoma, carcinoid tumors, and GISTs, each requiring specific treatments.
Persistent abdominal pain, unexplained weight loss, changes in bowel habits, and blood in the stool are concerning signs. Early detection improves treatment outcomes.
CT scans help visualize the small intestine's structure, identifying abnormalities like tumors.
A biopsy confirms cancer presence and identifies its specific type, guiding treatment plans.
Treatment options include surgery, chemotherapy, radiation therapy, and targeted therapy.
Yes, family history, previous radiation exposure, and certain genetic conditions are risk factors.
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